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- Title
γδ T Cells And Acute Primary Toxoplasma gondii Infection In Mice.
- Authors
Sayles, Peter C.; Rakhmilevich, Alexander L.; Johnson, Lawrence L.
- Abstract
A murine model of Toxoplasma gondiiinfection was used to investigate whether ãα T cells are required to resist primary acute toxoplasmosis. The surface phenotype of peritoneal exudate and spleen cells obtained from T. gondii-infected mice was examined using anti- ãα T cell-specific reagents and flow cytometry. Survival of mice depleted of ãα T cells was also followed during the acute phase of toxoplasmosis. Numbers of ãα T cells did not increase in spleen or peritoneal exudates of mice infected with T. gondii.Moreover, infected mice depleted of ãα T cells survived as long as untreated infected mice. These results indicate that ãα T cells do not play an important role in host defense against T. gondii infection in mice.
- Publication
Journal of Infectious Diseases, 1995, Vol 171, Issue 1, p249
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/171.1.249