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- Title
The Natural History of Infection with Hepatitis C Virus (HCV) in Chimpanzees: Comparison of Serologic Responses Measured with First- and Second- Generation Assays and Relationship to HCV Viremia.
- Authors
Farci, Patrizia; London, William T.; Wong, Doris C.; Dawson, George J.; Vallari, David S.; Engle, Ronald; Purcell, Robert H.
- Abstract
The sensitivity of first- and second-generation tests for antibody to hepatitis C virus (HCV) and the relationship among the patterns of antibody response and HCV viremia were examined in serial serum samples from 6 chimpanzees experimentally infected with HCV and followed ⩽3 years. HCV infection was transient in 4 chimpanzees and became chronic in 2. All chimpanzees developed antibodies to HCV detectable by second-generation assays, while only 5 of the 6 became positive by first-generation assay. Second-generation were consistently more sensitive than first-generation assays for the early diagnosis of primary HCV infection. The pattern observed with second-generation assays was not influencedby the outcome ofHCV infection, since antibodies remained persistently detectable throughout follow-up regardless of whether viremia was transient or persistent. In contrast, the first-generation antibody response was variable: It usually disappeared after loss of viremia, whereas its presence paralleled HCV viremia in chimpanzees with chronic infection.
- Publication
Journal of Infectious Diseases, 1992, Vol 165, Issue 6, p1006
- ISSN
0022-1899
- Publication type
Article