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- Title
Biological variation of homeostasis model assessment-derived insulin resistance in type 2 diabetes.
- Authors
Jayagopal, Vijay; Kilpatrick, Eric S.; Jennings, Paul E.; Hepburn, David A.; Atkin, Stephen L.
- Abstract
<bold>Objective: </bold>Individuals with type 2 diabetes are particularly vulnerable to cardiovascular disease. Insulin resistance is a major determinant of this increased risk and is a potential therapeutic target. This study was undertaken to establish the natural biological variation of insulin resistance in individuals with type 2 diabetes.<bold>Research Design and Methods: </bold>The biological variation of insulin resistance was assessed by measuring insulin resistance at 4-day intervals on 10 consecutive occasions in 12 postmenopausal women with diet-controlled type 2 diabetes and in 11 weight- and age-matched postmenopausal women without type 2 diabetes. Insulin resistance was derived using the homeostasis model assessment for insulin resistance (HOMA-IR) method.<bold>Results: </bold>The distribution of HOMA-IR was log Gaussian in the type 2 diabetic study group and Gaussian in the control group. The HOMA-IR in the type 2 diabetic group was significantly greater than that of the control group (mean +/- SD: 4.33 +/- 2.3 vs. 2.11 +/- 0.79 units, P = 0.001). After accounting for analytical variation, the mean intraindividual variation was also substantially greater in the type 2 diabetic group than in the control group (mean 1.05 vs. 0.15, P = 0.001). Consequently, at any level of HOMA-IR, a subsequent sample must increase by >90% or decrease by >47% to be considered significantly different from the first.<bold>Conclusions: </bold>HOMA-IR is significantly greater and more variable for individuals with type 2 diabetes. Therefore, this inherent variability needs to be accounted for in studies evaluating therapeutic reduction of HOMA-IR in this group.
- Subjects
INSULIN resistance; TYPE 2 diabetes; HOMEOSTASIS
- Publication
Diabetes Care, 2002, Vol 25, Issue 11, p2022
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.25.11.2022