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- Title
Was the historic contribution of Spain to the Mexican gene pool partially responsible for the higher prevalence of type 2 diabetes in mexican-origin populations? The Spanish Insulin Resistance Study Group, the San Antonio Heart Study, and the Mexico City Diabetes Study.
- Authors
Lorenzo, Carlos; Williams, Ken; Stern, Michel P.; Hazuda, Helen P.; Haffner, Steven M.; Serrano-Rios, Manel; Martinez-Larrad, Maria T.; Gabriel, Rafael; Gonzalez-Villalpando, Clicerio; Lorenzo, C; Serrano-Rios, M; Martinez-Larrad, M T; Gabriel, R; Williams, K; Gonzalez-Villalpando, C; Stern, M P; Hazuda, H P; Haffner, S M
- Abstract
<bold>Objective: </bold>Mexican-American populations in San Antonio, Texas (SA-MA) and Mexico have a higher prevalence of type 2 diabetes than non-Hispanic whites in San Antonio (SA-NHW). However, the higher prevalence of type 2 diabetes in Mexican-origin populations might be related, in part, not to Native American genetic admixture but to Spanish genetic admixture.<bold>Research Design and Methods: </bold>Four population-based epidemiological surveys conducted with Mexican-origin and European-origin samples provided data relevant to this question. In all four surveys, type 2 diabetes was defined as fasting plasma glucose > or =7.0 mmol/l or 2-h glucose > or =11.1 mmol/l or use of antidiabetic agents.<bold>Results: </bold>A comparison of the two Mexican-origin populations showed that the age- and sex-adjusted prevalence of type 2 diabetes was lower in Mexico than in SA-MA (15.1 vs. 17.9%, P = 0.032). Between the two European-origin populations, the prevalence of type 2 diabetes was lower in SA-NHW than in Spain (6.2 vs. 9.1%, P < 0.0001), but differences were attenuated by adjustment for BMI or after stratification by education. In logistic regression analyses, type 2 diabetes was associated with Mexican ethnic origin after adjusting for age, education, BMI, and waist-to-hip ratio.<bold>Conclusions: </bold>The prevalence of type 2 diabetes in Spain was intermediate between that in Mexican-origin populations and SA-NHW. Although the higher degree of Native American admixture is a major contributor to the higher rates of type 2 diabetes, we cannot completely rule out a partial contribution of Spanish admixture to diabetes susceptibility among Mexican- origin populations.
- Subjects
MEDICAL genetics; GENETICS of type 2 diabetes; HARPSICHORD concertos; MEXICANS; DISEASES
- Publication
Diabetes Care, 2001, Vol 24, Issue 12, p2059
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.24.12.2059