We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes.
- Authors
Emoto, Masanori; Kanda, Hiroyuki; Shoji, Tetsuo; Kawagishi, Takahiko; Komatsu, Miyoko; Mori, Katsuhito; Tahara, Hideki; Ishimura, Eiji; Inaba, Masaaki; Okuno, Yasuhisa; Nishizawa, Yoshiki; Emoto, M; Kanda, H; Shoji, T; Kawagishi, T; Komatsu, M; Mori, K; Tahara, H; Ishimura, E; Inaba, M
- Abstract
<bold>Objective: </bold>To assess the impacts of insulin resistance and renal function on plasma total homocysteine (tHcy) levels in patients with type 2 diabetes with a wide range of nephropathy.<bold>Research Design and Methods: </bold>Plasma tHcy levels were measured using the enzyme immunoassay method in 75 patients with type 2 diabetes and compared with those in 54 healthy control subjects. Insulin sensitivity indexes were assessed in patients with type 2 diabetes by hyperinsulinemic-euglycemic clamp using artificial pancreas.<bold>Results: </bold>Plasma tHcy levels and their log-translormed values (log tHcy) were significantly higher in all patients with diabetes than in control subjects (tHcy, 12.0 +/- 0.7 [SE] vs. 8.7 +/- 0.3 micromol/l, P < 0.0001; log tHcy, 1.040 +/- 0.021 vs. 0.920 +/- 0.016 micromol/l, P < 0.0001). Plasma tHcy levels in patients with diabetes were significantly increased according to degree of nephropathy (P < 0.0001). On simple regression analyses, log tHcy correlated with insulin sensitivity indexes (r = -0.319, P = 0.005) as well as creatinine clearance (r = 0.634, P < 0.0001) in all patients with diabetes. Multiple regression analyses showed that insulin sensitivity indexes (beta = -0.245) as well as creatinine clearance were independent contributors to log tHcy in all patients with diabetes (R2 = 0.750, P < 0.0001). For the 59 patients with diabetes with creatinine clearance >60 ml/min, insulin sensitivity indexes were also shown to be a significant contributor to log tHcy (beta = -0.438, R2 = 0.561, P < 0.001).<bold>Conclusion: </bold>Insulin resistance and renal function are independent determinants of tHcy levels in patients with type 2 diabetes.
- Subjects
INSULIN resistance; DIABETIC nephropathies; HOMOCYSTEINE; TYPE 2 diabetes
- Publication
Diabetes Care, 2001, Vol 24, Issue 3, p533
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.24.3.533