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- Title
An importance of carbohydrate ingestion for the expression of the effect of alpha-glucosidase inhibitor in NIDDM.
- Authors
Hara T; Nakamura J; Koh N; Sakakibara F; Takeuchi N; Hotta N; Hara, T; Nakamura, J; Koh, N; Sakakibara, F; Takeuchi, N; Hotta, N
- Abstract
<bold>Objective: </bold>To examine the usefulness of alpha-glucosidase inhibitors in glycemic control of patients with NIDDM. The involvement of carbohydrate ingestion in manifestation of the effects of alpha-glucosidase inhibitors was also investigated.<bold>Research Design and Methods: </bold>A total of 41 patients hospitalized with NIDDM (22 patients receiving sulfonylurea and 19 receiving insulin therapy) were given alpha-glucosidase inhibitors during the period when their blood glucose levels were well controlled. They were followed for 3 weeks as inpatients and for an additional 6 months as outpatients. They were retrospectively divided into two groups according to the percentage of carbohydrates in all sources of calories during outpatient management: the < 50% group and the > 50% group. Between these two groups, we compared circadian variation in blood glucose levels, HbA1c, and urine C-peptide.<bold>Results: </bold>Treatment with alpha-glucosidase inhibitors during the hospital stay markedly improved circadian variation in blood glucose levels and HbA1c and decreased urine C-peptide in both groups. While HbA1c returned to its pretreatment level at 6 months after the treatment in the < 50% group, HbA1c had further improved in the > 50% group at 6 months.<bold>Conclusions: </bold>alpha-Glucosidase inhibitors are useful for glycemic control in patients with NIDDM and the percentage of carbohydrate in all calorie sources is an important factor for the expression of their effects.
- Publication
Diabetes Care, 1996, Vol 19, Issue 6, p642
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.19.6.642