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- Title
Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome.
- Authors
Karasik, A; O'Hara, C; Srikanta, S; Swift, M; Soeldner, J S; Kahn, C R; Herskowitz, R D
- Abstract
Insulin-producing beta-cells were selectively absent from the islets of Langerhans in postmortem specimens from two patients with Wolfram's syndrome. In families with multiple cases of this syndrome, we found a very high concordance rate (r = .910, P less than .001) among siblings for age at onset of diabetes mellitus. Taken together with the lack of markers for an autoimmune process, these findings suggest that diabetes mellitus in this syndrome results from genetically programmed selective beta-cell death.
- Publication
Diabetes Care, 1989, Vol 12, Issue 2, p135
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.12.2.135