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- Title
ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients.
- Authors
Yu, Songlin; Ma, Samantha J.; Liebeskind, David S.; Yu, Dandan; Li, Ning; Qiao, Xin J.; Shao, Xingfeng; Yan, Lirong; Yoo, Bryan; Scalzo, Fabien; Hinman, Jason D.; Sharma, Latisha K.; Rao, Neal; Jahan, Reza; Tateshima, Satoshi; Duckwiler, Gary R.; Saver, Jeffrey L.; Salamon, Noriko; Wang, Danny J. J.
- Abstract
The purpose of this study was to develop and evaluate a scoring system for assessing reperfusion status based on arterial spin labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) patients receiving thrombolysis and/or endovascular treatment. Pseudo-continuous ASL with background suppressed 3D GRASE was acquired along with DWI in 90 patients within 24 h post-treatment. An automatic reperfusion scoring system (auto-RPS) was devised based on the Alberta Stroke Program Early CT Score (ASPECTS) template, and compared with manual RPS and DWI-ASPECTS. TICI (thrombolysis in cerebral infarction) scores were graded in 48 patients who received endovascular treatment. Favorable outcomes were defined by a modified Rankin Scale score of 0–2 at three months. Auto-RPS was positively correlated with DWI-ASPECTS (ρ = 0.6, P < 0.001) and was on average 1 point lower than DWI-ASPECTS (P < 0.001). The area under the receiver operating characteristic curve for discriminating poor functional outcome (n = 90) was 0.75 (95% CI, 0.64–0.86) for manual RPS, 0.85 (95% CI, 0.76–0.94) for auto-RPS, and 0.81 (95% CI, 0.71–0.90) for DWI-ASPECTS. Multiple logistic regression analysis in the TICI-graded patients (n = 48) showed that auto-RPS is highly associated with functional outcome (OR = 25.2, 95% CI 4.02–496, P < 0.01). Post treatment auto-RPS within 24 h provides a useful tool to predict functional outcome in AIS patients.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2018, Vol 38, Issue 3, p382
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1177/0271678X17697339