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- Title
Morphological and immunohistochemical diversity of endometrial stromal sarcoma in rats.
- Authors
Shino Kumabe; Junko Sato; Yuki Tomonari; Miwa Takahashi; Kaoru Inoue; Midori Yoshida; Takuya Doi; Yumi Wako; Minoru Tsuchitani
- Abstract
To clarify the histopathological characteristics of rat endometrial stromal sarcoma (ESS), we morphologically reviewed 12 malignant uterine tumors protruding into the lumen in previous rat carcinogenicity studies. The 12 cases were classified into the following 6 types based on their morphological features: spindle cell and collagen rich type, pleomorphic/spindle cell and compact type, decidual alteration type, histiocytic and multinucleated giant cell mixture type, Antoni A-type schwannoma type, and Antoni B-type schwannoma type. Immunohistochemically, tumor cells in all cases exhibited focal or diffuse positive reactions for vimentin and 11 of the 12 cases were positive for S-100. Interestingly, 9 cases were positive for desmin or αSMA, indicating tumor cells expressing smooth muscle properties. Both Antoni A- and B-type schwannoma types showed low reactions for both muscle markers. Positive results for estrogen receptor α in the 11 cases suggested that they were derived from endometrial stromal cells. On the basis of their immunohistochemical profiles, they were considered to be derived from endometrial stromal cells while they showed morphological variation. The detection of a basement membrane surrounding tumor cells might not be a definitive indicator for differential diagnosis of ESS from malignant schwannoma. In conclusion, ESS could exhibit wide morphological and immunohistochemical variation including features of schwannoma or smooth muscle tumor.
- Subjects
SARCOMA; UTERINE tumors; SCHWANNOMAS; VIMENTIN; IMMUNOHISTOCHEMISTRY
- Publication
Journal of Toxicologic Pathology, 2018, Vol 31, Issue 2, p95
- ISSN
0914-9198
- Publication type
Article
- DOI
10.1293/tox.2017-0056