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- Title
Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon.
- Authors
Sales, C. A.; Pinto-Silva, M. C. F.; Bardález-Rivera, J. G.; Abreu-Alberio, C. A.; Sena, L. W. P.; Vieira, J. L. F.
- Abstract
This study aimed to correlate the values of liver markers with oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon. A total of 30 patients from the Tuberculosis clinic of a referral hospital were admitted to the study. Whole blood samples were collected for analysis of liver enzyme values and oxidative stress markers by spectrophotometry. The prevalence was male (60%) and the 18-29 age group was the most affected. Patients with multidrug-resistant tuberculosis presented catalase values with a median equal to 6.94 U/gHb and for glutathione, the median was equal to 14.76 µg∕ml. As for the values of liver enzymes (AST, ALT, Gamma-GT and Alkaline phosphatase) the patients had medians equal to 60.50 (U/L); 80 (U/L); 54 (U/L); and 100 (U/L) respectively (p<0.0001). The results suggest a hepatotoxic effect of the drug, which recommends further studies with a larger number of samples in order to investigate the predictors of liver damage in patients with multidrug-resistant tuberculosis.
- Publication
Brazilian Journal of Biology, 2023, Vol 83, p1
- ISSN
1519-6984
- Publication type
Article
- DOI
10.1590/1519-6984.272512