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- Title
HIV: Crucial crossing.
- Authors
Molloy, Sheilagh
- Abstract
The article highlights a research conducted by Jason Brenchley and colleagues regarding HIV-1 and simian immunodeficiency virus (SIV) infections in the U.S. The research proves that the systemic immune activation which happens during chronic HIV-1 infection is linked to the translocation of microbial products from the intestinal lumen. Thus, it is linked to damage to the structural integrity of the gut epithelial layer and impaired clearance by macrophages.
- Subjects
UNITED States; HIV infections; SIV antibodies; MICROBIAL products; BIOLOGICAL products; MACROPHAGES; BRENCHLEY, Jason
- Publication
Nature Reviews Microbiology, 2010, Vol 8, Issue 10, p678
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2443