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- Title
Preoperative neurocognitive evaluation of brain tumor patients.
- Authors
Hendrix, Philipp; Hans, Elisa; Oertel, Joachim; Karbach, Julia
- Abstract
Introduction: Patients suffering from benign or malignant brain tumors may experience neurological or neuropsychological impairments. Here, we seek to determine which patient subgroups exhibit preoperative neurocognitive dysfunctions and moreover, assess which neuropsychological test is adequate for uncovering these deficits. Methods: Forty-five brain tumor patients underwent neurocognitive testing via an extensive neuropsychological testbattery consisting of digit symbol subsitution test, digit span test, corsi block test, verbal learning and memory test, stroop test, trail making test A and B, Regensburg verbal fluency test, Wechsler adult intelligence matrix reasoning and hospital anxiety and depression scale. Inclusion criteria were informed consent, a Karnofsky performance status ≥ 60, exclusion of neurological dysfunctions that interfere with adequate neuropsychological assessment as dysphasia, paralysis of dominant hand, visual impairments, psychiatric disorders, sedative medication and obvious neuropsychological deficits perceivable in a bed-side-setting. Results: The patient cohort suffered either from pituitary adenoma (14), meningioma (14), cerebral metastases (10) or glioblastoma mutiforme (7). The average Karnofsky performance score was 90 (±10). Tumor entity and tumor size were not associated with differences in neurocognitive performance. Patients with tumors compromising the frontal lobe performed significantly poorer in formal lexical word fluency tasks compared to non-frontal lobe tumors. Additionally, frontal lobe tumor patients displayed significantly higher anxiety and depression scores. Patients that presented with postural instability and/or gait abnormality displayed poorer performance on the perceptual speed task and the formal lexical word fluency task. Discussion: Tumor localization and neurological presentation, but not tumor entity or tumor size are associated with poorer preoperative neurocognitive performance in a subset of neuropsychological tests.
- Subjects
COGNITION disorders; BRAIN tumors; NEUROPSYCHOLOGICAL tests; PREOPERATIVE period; VERBAL learning; ANXIETY; MENTAL depression; PATIENTS
- Publication
Zeitschrift für Neuropsychologie, 2015, Vol 26, Issue 3, p207
- ISSN
1016-264X
- Publication type
Abstract