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- Title
Pathogenesis of endometrium‐related diseases based on genomic alterations in normal uterine endometrium.
- Authors
Yoshihara, Kosuke
- Abstract
The human endometrium is a dynamically remodeling tissue that undergoes more than 400 cycles of regeneration, differentiation, shedding, and rapid healing during a woman's reproductive years. The endometrium is also the origin of various gynecologic diseases, such as endometriosis, adenomyosis, and uterine corpus cancer. Cancer‐associated gene mutations are detected in endometriosis, adenomyosis, and normal endometrium. Some reports have demonstrated that the accumulation of genomic alterations is a critical carcinogenic mechanism in the progression from normal endometrium to ovarian clear cell carcinoma via endometriosis. In this review, we discuss the clinical importance of genomic alterations in the normal endometrium, contributing to the elucidation of the pathogenesis of endometrium‐related diseases.
- Subjects
ENDOMETRIOSIS; DISEASE progression; ENDOMETRIAL diseases; GENETIC mutation; OVARIAN tumors; UTERINE tumors; RISK assessment; ENDOMETRIUM; DISEASE risk factors
- Publication
Journal of Obstetrics & Gynaecology Research, 2023, Vol 49, Issue 8, p2023
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.15680