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- Title
Intermolecular Amination of Unactivated C(sp<sup>3</sup>)−H Bonds with Cyclic Alkylamines: Formation of C(sp<sup>3</sup>)−N Bonds through Copper/Oxygen-Mediated C(sp<sup>3</sup>)−H/N−H Activation.
- Authors
Gou, Quan; Yang, Yu ‐ Wen; Liu, Zi ‐ Ning; Qin, Jun
- Abstract
The first example of intermolecular amination of unactivated C(sp3)−H bonds by cyclic alkylamines mediated by Cu(OAc)2/O2 is reported. This method avoids the use of benzoyloxyamines as the aminating reagent, which are normally prepared from alkylamines in extra steps. A variety of unnatural β2, 2-amino acid analogues are synthesized by this simple and efficient procedure. This approach offers a solution to the previous unmet challenge of C(sp3)−H/N−H activation for the formation of C(sp3)−N bonds.
- Subjects
AMINATION; VOIGT reaction; HYDROGEN bonding; ALKYLAMINES; CHEMICAL bonds
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 45, p16057
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201603370