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- Title
Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible-Light-Triggered Platform for Facile siRNA Delivery.
- Authors
Patil, Sachin P.; Moosa, Basem A.; Alsaiari, Shahad; Alamoudi, Kholod; Alshamsan, Aws; AlMalik, Abdulaziz; Adil, Karim; Eddaoudi, Mohamed; Khashab, Niveen M.
- Abstract
Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light-responsive nanostructures. Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible-light irradiation leading up to 90% of gene silencing in live cells.
- Subjects
ANTHRACENE; AROMATIC compounds spectra; HISTIDINE; ANTHRACENE crystals; HYDROGEN bonding; SMALL interfering RNA; SUPRAMOLECULAR chemistry
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 39, p13789
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201601442