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- Title
A Prospective Multicenter Study Evaluating Bleeding Risk after Endoscopic Ultrasound-Guided Fine Needle Aspiration in Patients Prescribed Antithrombotic Agents.
- Authors
Kazumichi Kawakubo; Kei Yane; Kazunori Eto; Hirotoshi Ishiwatari; Nobuyuki Ehira; Shin Haba; Ryusuke Matsumoto; Keisuke Shinada; Hiroaki Yamato; Taiki Kudo; Manabu Onodera; Toshinori Okuda; Yoko Taya-Abe; Shuhei Kawahata; Kimitoshi Kubo; Yoshimasa Kubota; Masaki Kuwatani; Hiroshi Kawakami; Akio Katanuma; Michihiro Ono
- Abstract
Background/Aims: Although the risk of bleeding after endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is low, the safety of EUS-FNA in patients prescribed antithrombotic agents is unclear. Therefore, this study evaluated the incidence of bleeding after EUS-FNA in those patients. Methods: Between September 2012 and September 2015, patients who were prescribed antithrombotic agents underwent EUS-FNA at 13 institutions in Japan were prospectively enrolled in the study. The antithrombotic agents were managed according to the guidelines of the Japanese Gastrointestinal Endoscopy Society. The rate of bleeding events, thromboembolic events and other complications within 2 weeks after EUS-FNA were analyzed. Results: Of the 2,629 patients who underwent EUS-FNA during the study period, 85 (62 males; median age, 74 years) patients were included in this stduy. Two patients (2.4%; 95% confidence interval [CI], 0.6% to 8.3%) experienced bleeding events. One patient required surgical intervention for hemothorax 5 hours after EUS-FNA, and the other experienced melena 8 days after EUS-FNA and required red blood cell transfusions. No thromboembolic events occurred (0%; 95% CI, 0.0% to 4.4%). Three patients (3.5%; 95% CI, 1.2% to 10.0%) experienced peri-puncture abscess formation. Conclusions: The rate of bleeding after EUS-FNA in patients prescribed antithrombotic agents might be considerable.
- Subjects
HEMORRHAGE risk factors; NEEDLE biopsy; BIOPSY complications; ANTICOAGULANTS; ENDOSCOPIC ultrasonography
- Publication
Gut & Liver, 2018, Vol 12, Issue 3, p353
- ISSN
1976-2283
- Publication type
Article
- DOI
10.5009/gnl17293