We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypoxia enhances the protective effects of placenta-derived mesenchymal stem cells against scar formation through hypoxia-inducible factor-1α.
- Authors
Du, Lili; Lv, Runxiao; Yang, Xiaoyi; Cheng, Shaohang; Xu, Jing; Ma, Tingxian
- Abstract
Objectives: To explore the effect of placenta-derived mesenchymal stem cells on scar formation as well as the underlying mechanism. Results: The isolated placenta-derived mesenchymal stem cells from mice were distributed in the wounded areas of scalded mouse models, attenuated inflammatory responses and decreased the deposition of collagens, thus performing a beneficial effect against scar formation. Hypoxia enhanced the protective effect of placenta-derived mesenchymal stem cells and hypoxia-inducible factor-1α was involved in the protective effect of placenta-derived mesenchymal stem cells in hypoxic condition. Conclusions: Hypoxia enhanced the protective effect of placenta-derived mesenchymal stem cells through hypoxia-inducible factor-1α and PMSCs may have a potential application in the treatment of wound.
- Subjects
HYPOXEMIA; MESENCHYMAL stem cells; HYPOXIA-inducible factor 1; WOUND care; LABORATORY mice; THERAPEUTICS
- Publication
Biotechnology Letters, 2016, Vol 38, Issue 6, p931
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-016-2067-6