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- Title
Synthesis of novel halo and tosyloxy nortropane derivatives as efficient precursors for the one-step synthesis of the dopamine transporter PET ligand [<sup>18</sup>F]FECNT.
- Authors
Pijarowska ‐ Kruszyna, J.; Jaron, A. W.; Kachniarz, A.; Kasprzak, K.; Kowalska, A.; Malkowski, B.; Demphel, S.; Dollé, F.; Mikolajczak, R.
- Abstract
The fluorine-18 labeled nortropane derivative 2 β-carbomethoxy-3 β-(4-chlorophenyl)-8-(2-fluoroethyl)-nortropane (FECNT) is a dopamine transporter (DAT) ligand. Currently, it is considered as reference for positron emission tomography imaging. Herein, the synthesis of novel precursors ( N-tosyloxy-, chloro-, and bromo- analogues) for one-step radiosynthesis of [18F]FECNT is reported. Using the N-mesyloxy- precursor in a one-step radiosynthesis, the crude [18F]FECNT was obtained with the radiolabeling yield of 45 ± 10%, confirming the practical efficiency of this approach in the design of novel precursors for labeling.
- Subjects
CHEMICAL synthesis; FLUORINATION; DOPAMINE; CHEMICAL precursors; POSITRON emission tomography
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2014, Vol 57, Issue 3, p148
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3181