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- Title
Function and Interactions of ERCC1-XPF in DNA Damage Response.
- Authors
Faridounnia, Maryam; Folkers, Gert E.; Boelens, Rolf; Iwahara, Junji
- Abstract
Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1.
- Subjects
PHYSIOLOGICAL effects of proteins; DNA damage; GENOMES; ENDONUCLEASE genetics; DNA repair
- Publication
Molecules, 2018, Vol 23, Issue 12, p3205
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23123205