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- Title
Liposomes as Carrier of Methyl-GAG.
- Authors
Arndt, D.; Fichtner, I.; Nissen, E.
- Abstract
The encapsulation efficiency and the leakage on storage of various types of liposomes prepared from different lipid compositions containing the anticancer drug methyl-GAG (methylglyoxal-bis-guanylhydrazone) were investigated. Treatment with methyl-GAG in a q.d. 1-4 schedule resulted in the murine leukemias P 388 and L 1210 (i.v.) in nearly the same increase in life span as the corresponding dose in liposomes. In a q.d. 1, 3 schedule methyl-GAG containing liposomes revealed comparable effects as the 4-day treatment with the free drug. The hypoglycemic effect of 80 mg/kg methyl-GAG, q.d. 1-4, could be normalized when the drug was administered in reverse-phase evaporation vesicles. We conclude that the liposomal encapsulation of methyl-GAG leads to a depot effect with a slight relief of toxicity. Copyright © 1987 S. Karger AG, Basel
- Publication
Oncology, 1987, Vol 44, Issue 4, p257
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000226490