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- Title
A Phase II Study of Three-Weekly Docetaxel and Weekly Trastuzumab in HER2-Overexpressing Advanced Breast Cancer.
- Authors
Montemurro, Filippo; Choa, Gabriella; Faggiuolo, Roberto; Donadio, Michela; Minischetti, Monica; Durando, Antonio; Capaldi, Antonio; Vietti-Ramus, Guido; Alabiso, Oscar; Aglietta, Massimo
- Abstract
Background: To test safety and activity of 3-weekly doses of docetaxel and a weekly dose of trastuzumab in women with HER2-overexpressing advanced breast cancer. Patients and Methods: Forty-two women, median age 53 years (range 36–73 years), with HER2-overexpressing advanced breast cancer were enrolled in a study of docetaxel, 75 mg/m[sup 2] q3w for 6 cycles, and trastuzumab, 4 mg/kg loading dose, 2 mg/kg weekly thereafter. Thirty-four patients (81%) had visceral metastatic involvement. Thirty-five patients had received prior chemotherapy as part of their treatment: adjuvant/neoadjuvant (26), metastatic (2) and both (7). Thirty-one patients had been previously exposed to an anthracycline and 11 to paclitaxel. Four patients had previously received high-dose chemotherapy followed by autologous stem cell transplant. Results: 226 cycles (median 6, range 1–6) were administered. The median delivered dose intensity for docetaxel was 24 mg/m[sup 2] /week (range 16–25 mg/m[sup 2] /week). The intent to treat overall response rate was 67% (95% confidence interval, 52–79%). Median progression-free survival, time to treatment failure, and duration of response were 9, 8 and 12 months, respectively. Symptomatic cardiotoxicity (grade 3) occurred in 1 patient. The most common grade 3/4 toxicity was neutropenia (76% of the patients), although febrile neutropenia did not occur. Conclusions: Three-weekly doses of docetaxel and a weekly dose of trastuzumab is an active and safe combination in patients with HER2-overexpressing advanced breast cancer. Copyright © 2004 S. Karger AG, Basel
- Subjects
BREAST cancer; TUMORS; DOCETAXEL; TRASTUZUMAB; METASTASIS
- Publication
Oncology, 2004, Vol 66, Issue 1, p38
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000076333