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- Title
Metabolism of inflammation limited by AMPK and pseudo-starvation.
- Authors
O'Neill, Luke A. J.; Hardie, D. Grahame
- Abstract
Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1? and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.
- Subjects
MACROPHAGES; GLUCOSE; GLYCOLYSIS; T cells; ANTI-inflammatory agents; PROTEIN kinases; STARVATION; KILLER cells
- Publication
Nature, 2013, Vol 493, Issue 7432, p346
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature11862