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- Title
REVIEW ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF GENUS FERULA.
- Authors
Kheir Boukhary, Rima Mohammad; Omeiche, Zeina; Hijazi, Mohamad Ali; Assi, Ali Wassef; Houri, Tamar
- Abstract
Genus Ferula comprises about 220 species of flowering plants belonging to family Apiaceae, distributed in the Mediterranean region and Asia and used in the treatment of different diseases as anti-oxidant, aphrodisiac, carminative, antinociceptive, anti-depressant, antibacterial, anti-fungal, anti-leishmanial, and anti-inflammatory. Moreover, species of this plant are used for dizziness, asthma, bronchitis, and gastrointestinal discomfort. It was reported that all the pharmacological effects of these plants are due to the presence of different phenolic constituents including flavonoids, sesquiterpenes, coumarins and polysulfides. Sesquiterpene coumarins were responsible for the anti-inflammatory and anti-cancer activities by blocking the 5-lipoxygenase enzyme that catalyzes the biosynthesis of leukotrienes (LTs) being a group of lipid mediators of inflammation. This review covers most of the identified chemical constituents of plants from the genus Ferula reported in literature between 2001 and 2023. In addition, the biological activities of the different species of genus Ferula are presented.
- Subjects
FERULA; UMBELLIFERAE; ANTIOXIDANT analysis; ANTIFUNGAL agents; LEUKOTRIENES; ANTINEOPLASTIC agents
- Publication
BAU Journal - Health & Well-Being, 2024, Vol 6, Issue 1, p1
- ISSN
2617-1635
- Publication type
Article
- DOI
10.54729/2789-8288.1200