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- Title
(Light) remote control of the brain.
- Authors
Wiedemann, Claudia
- Abstract
The article presents a research by Karl Deisseroth and colleagues which employs two light-activated proteins that would remotely control the activity of rat hippocampal neurons and the behavior of the nematode Caenorhabditis elegans. The authors used lentivirus to transfect the brain of mouse pups and the hippocampi of adult mice with Natronomonas pharanois (NpHR) and channelrhodopsin (ChR2). The study indicated that ChR2 and NpHR can possibly control the neuronal activity in vivo.
- Subjects
NEUROLOGICAL research; DEISSEROTH, Karl; PROTEINS; HIPPOCAMPUS (Brain); LENTIVIRUS diseases; NEURONS; ANIMAL models in research; MENTAL suggestion; BEHAVIOR modification
- Publication
Nature Reviews Neuroscience, 2007, Vol 8, Issue 5, p328
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn2143