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- Title
Weeding out dopaminergic neurons.
- Authors
Welberg, Leonie
- Abstract
The article investigates the role of environmental and genetic component on the etiology of Parkinson’s disease (PD). The researchers showed that, in Drosophila, genes involved in dopamine synthesis and metabolism influence the susceptibility of dopaminergic neurons to oxidative damage caused by the herbicide paraquat. These findings clearly show how genetic and environmental factors can interact to cause neurodegeneration in a Drosophila model.
- Subjects
PARKINSON'S disease; ETIOLOGY of diseases; ENVIRONMENTALLY induced diseases; MEDICAL genetics; DROSOPHILA; MEDICAL model; NEURODEGENERATION; ANIMAL disease models
- Publication
Nature Reviews Neuroscience, 2007, Vol 8, Issue 4, p247
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn2122