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- Title
Adenosine A<sub>1</sub> Receptor Blockade Mimics Caffeine's Attenuation of Ethanol-Induced Motor Incoordination.
- Authors
Connole, Laura; Harkin, Andrew; Maginn, Mark
- Abstract
The effects of co-administration of caffeine and ethanol were assessed on the motor coordination of rats on the accelerating rotarod (accelerod). Ethanol (2.5 g/kg, orally) decreased motor performance on the accelerod. Co-administration of caffeine (5 and 20 mg/kg, orally) dose-dependently attenuated this ethanol-induced deficit. Caffeine (20 mg/kg, orally) alone did not affect motor performance in the test. As caffeine is a non-selective adenosine receptor antagonist the ability of adenosine A1 and A2A receptor blockade to attenuate ethanol-induced motor incoordination was determined. Pre-treatment with the adenosine A1 receptor antagonist DPCPX (5 mg/kg, intraperitoneally) attenuated ethanol (2.5 g/kg, orally)-induced motor incoordination. By contrast, prior administration of the adenosine A2A selective antagonist SCH 58261 (10 mg/kg intraperitoneally) had no effect on the ethanol-induced motor deficit. These data demonstrate that adenosine A1 receptor blockade mimics the inhibitory action of caffeine on ethanol-induced motor incorordination, and may contribute to the ability of caffeine to offset the acute intoxicating actions of ethanol.
- Subjects
ADENOSINES; ADENINE; CAFFEINE; ALCOHOL; TOXICOLOGY; PHARMACOLOGY; MEDICAL sciences
- Publication
Basic & Clinical Pharmacology & Toxicology, 2004, Vol 95, Issue 6, p299
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2004.pto950509.x