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- Title
Activity-based anorexia during adolescence does not promote binge eating during adulthood in female rats.
- Authors
Wenli Cai; Bocarsly, Miriam E.; Arner, Candice N.; Walsh, B. Timothy; Foltin, Richard W.; Hoebel, Bartley G.; Barbarich-Marsteller, Nicole C.
- Abstract
Objective: Given the frequency of transition from anorexia nervosa to bulimia nervosa, this study investigated whether a history of activity-based anorexia (ABA) during adolescence would promote binge eating during adulthood in female rats. Method: Adolescent rats were given 1-h unlimited access to chow and ad libitum access to a running wheel until body weight reached <80%, indicating the development of ABA. During adulthood, all groups were given 21 days of access to a palatable food for 2 h/day and ad libitum access to chow. Results: During adolescence, rats in the ABA paradigm developed increased wheel running and decreased food intake, reaching <80% of body weight after 3 days. However, there were no significant differences between groups in the amount of binge food consumed during adulthood. Conclusion: A brief episode of ABA during adolescence did not lead to increased binge eating later in life. Longer-term models are needed to determine whether a propensity toward binge eating may result from more sustained ABA during adolescence. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2008
- Subjects
ANOREXIA nervosa; BULIMIA; BODY weight; EATING disorders; ADOLESCENCE
- Publication
International Journal of Eating Disorders, 2008, Vol 41, Issue 8, p681
- ISSN
0276-3478
- Publication type
Article
- DOI
10.1002/eat.20568