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- Title
Major histocompatibility complex class I genes in primates: co-evolution with pathogens.
- Authors
Vogel, Thorsten U.; Evans, David T.; Urvater, Julie A.; O'Connor, David H.; Hughes, Austin L.; Watkins, David I.
- Abstract
The major histocompatibility complex (MHC) is the most polymorphic genetic system known, playing a central role in the cellular immune response to pathogens. The relationship between the MHC of humans and non-human primates has increased our understanding of MHC evolution and how polymorphism of this gene family may have been generated. We will review MHC class I evolution in great apes and Old World and New World primates and discuss new data from the simian immunodeficiency virus/rhesus monkey animal model that demonstrate the role of MHC class I alleles in selecting for new populations of viruses. This suggests that certain pathogens co-evolve with the MHC class I molecules they encounter in a population.
- Subjects
MAJOR histocompatibility complex; PRIMATES; PATHOGENIC microorganisms
- Publication
Immunological Reviews, 1999, Vol 167, Issue 1, p327
- ISSN
0105-2896
- Publication type
Article
- DOI
10.1111/j.1600-065X.1999.tb01402.x