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- Title
CYTOTOXICITY AND ANTIVIRAL ACTIVITY OF NOVEL FLUORIC COMPOUNDS.
- Authors
Naumenko, K.; Golovan, A.; Zagorognya, S.; Nesteroba, N.; Siryy, S.; Markitanov, Yu.; Tymoshenko, V.; Shermolovytch, Yu.
- Abstract
The cytotoxicity and antiviral nucleoside activity of fluoric compounds in EBV model systems were investigated in vitro. The apoptosis-stimulating effect was found for compound SBIO-6, that makes it perspective for further research in the area of antitumor analysis. The results can be used in computer modeling of the structure-biological activity relationships of substances and will be used for development of new highly efficient antiviral agents.
- Subjects
MOLECULAR toxicology; ANTIVIRAL agents; FLUORINE compounds; EPSTEIN-Barr virus; APOPTOSIS; IN vitro studies
- Publication
Bulletin of Taras Shevchenko National University of Kyiv / Vestnik Kievskogo Nacionalnogo Universiteta Imeni Tarasa Sevcenko, 2013, Vol 65, Issue 3, p82
- ISSN
1728-2748
- Publication type
Article