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- Title
Velocity storage mechanism in zebrafish larvae.
- Authors
Chen, Chien‐Cheng; Bockisch, Christopher J.; Bertolini, Giovanni; Olasagasti, Itsaso; Neuhauss, Stephan C. F.; Weber, Konrad P.; Straumann, Dominik; Ying‐Yu Huang, Melody
- Abstract
Key points Five-day-old zebrafish larvae already exhibit a velocity storage mechanism (VSM)., The VSM in zebrafish larvae emerges earlier than a functional horizontal angular vestibular reflex., The VSM may be critical to ocular motor control in larval zebrafish., Abstract The optokinetic reflex (OKR) and the angular vestibulo-ocular reflex (aVOR) complement each other to stabilize images on the retina despite self- or world motion, a joint mechanism that is critical for effective vision. It is currently hypothesized that signals from both systems integrate, in a mathematical sense, in a network of neurons operating as a velocity storage mechanism (VSM). When exposed to a rotating visual surround, subjects display the OKR, slow following eye movements frequently interrupted by fast resetting eye movements. Subsequent to light-off during optokinetic stimulation, eye movements do not stop abruptly, but decay slowly, a phenomenon referred to as the optokinetic after-response (OKAR). The OKAR is most likely generated by the VSM. In this study, we observed the OKAR in developing larval zebrafish before the horizontal aVOR emerged. Our results suggest that the VSM develops prior to and without the need for a functional aVOR. It may be critical to ocular motor control in early development as it increases the efficiency of the OKR.
- Subjects
ZEBRA danio; VESTIBULO-ocular reflex; REGULATION of eye movements; VESTIBULAR apparatus; LARVAE
- Publication
Journal of Physiology, 2014, Vol 592, Issue 1, p203
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2013.258640