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- Title
Successful treatment of Trichosporon fungemia in a patient with refractory acute myeloid leukemia using voriconazole combined with liposomal amphotericin B.
- Authors
Hosokawa, K.; Yamazaki, H.; Mochizuki, K.; Ohata, K.; Ishiyama, K.; Hayashi, T.; Kondo, Y.; Sugimori, N.; Okumura, H.; Takami, A.; Nakao, S.
- Abstract
Trichosporon fungemia is a rare and fatal fungal infection that occurs in patients with prolonged neutropenia associated with hematologic malignancies. A 21-year-old male developed Trichosporon fungemia during remission induction therapy for acute myeloid leukemia ( AML). Although two courses of induction therapy failed to induce a remission of AML, combination therapy with voriconazole and liposomal amphotericin B ( L-AmB) followed by monocyte colony-stimulating factor ameliorated the Trichosporon fungemia and enabled the patient to receive reduced-intensity bone marrow transplantation ( BMT) from his human leukocyte antigen-A one-locus mismatched mother. The patient achieved a durable remission after BMT without exacerbation of Trichosporon fungemia. The combination therapy with voriconazole and L-AmB may therefore be useful in controlling Trichosporon fungemia associated with prolonged neutropenia after remission induction therapy for AML.
- Subjects
CASE studies; MYCOSES; NEUTROPENIA; ACUTE myeloid leukemia; AMPHOTERICIN B
- Publication
Transplant Infectious Disease, 2012, Vol 14, Issue 2, p184
- ISSN
1398-2273
- Publication type
Article
- DOI
10.1111/j.1399-3062.2011.00670.x