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- Title
LYMPH NODE RATIO AS A PROGNOSTIC FACTOR IN PATIENTS WITH RECTAL CANCER.
- Authors
Ince, Mehmet; Yavuz, Ozdemir; Ziya, Balta Ahmet; Kazim, Duman; Ergun, Yucel; Ilker, Sucullu; Levhi, Akin Mehmet
- Abstract
MATERIAL AND METHOD: A total of 130 patients who had rectal adenocarcinoma and operated between 1996- 2011 years at our clinic. Age, gender, CEA, the type of surgery, disease free and 5-year survival, degree of differentiation of tumor and other features were retrieved retrospectively from our database. Patients were stratified into 4 groups according to the LNR quartiles of 1/12, 1/4, 1/2 and 1. The relationship between disease- free/overall survival and LNR was investigated. The cumulative survival ratios for LNR, N stage and TNM stage were calculated by the Kaplan Meier method and survival difference between groups were calculated by the log rank test. RESULTS: The mean number of lymph nodes examined was 11.5±8. In 75 (57.7%) of all patients fewer than 12 lymph nodes were harvested. Seventy-six (58.5%) patients were evaluated as N0, 35(26.9%) were N1 and 19(14.6%) were N2. The number of patients in 4 groups of LNR was 87(66.9%), 13 (10%), 17(13%) and 13(10%); respectively. 5-year survival rate was groups of LNR were 53.8%, 31.3%, 44.9% and 20.8%, respectively. A statistically significant between LNR and with the diseasefree survival (p<0.001), and overall survival (p<0.001) showed that LNR is a prognostic. CONCLUSION: LNR is the most significant prognostic factor for both overall and disease-free survival in patients with rectal cancer, even in patients with insufficient lymph node dissection and can be used to deciding adjuvant therapy.
- Publication
Balkan Military Medical Review, 2013, Vol 16, p125
- ISSN
1107-6275
- Publication type
Article