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- Title
MicroRNAs in Basolateral Amygdala Associated with Stress and Fear Memories Regulate Rapid Eye Movement Sleep in Rats.
- Authors
Balakathiresan, Nagaraja S.; Bhomia, Manish; Zhai, Min; Sweeten, Brook L. W.; Wellman, Laurie L.; Sanford, Larry D.; Knollmann-Ritschel, Barbara
- Abstract
Stress-related sleep disturbances are distressing clinical symptoms in posttraumatic stress disorder patients. Intensely stressful events and their memories change rapid eye movement (REM) sleep in animal models. REM sleep varies with individual differences of stress resilience or vulnerability. The basolateral amygdala (BLA) is a primary mediator of the effects of stress and fear memories on sleep. However, the molecular mechanisms in BLA regulating the effects of fear conditioning, shock training (ST) and context re-exposure (CTX) on REM sleep are not well known. MicroRNAs (miRNAs) are small, non-coding RNAs and posttranscriptional gene regulators of diverse biological processes. The aim of this study is to investigate ST- and CTX-altered miRNAs in the BLA of resilience and vulnerable animals and on REM sleep regulation. MiRNAs expression profiles in BLA were generated following ST and CTX using the Taqman Low Density rodent microRNA array. The altered BLA miRNAs expression and REM sleep reduction observed in ST and CTX vulnerable animals. AntagomiR-221 microinjection into BLA for one of the upregulated miRNAs, miR-221 in BLA, attenuated the REM sleep reduction. This study suggests that miRNAs in the BLA may play a significant role in mediating the effects of stress and fear memories on REM sleep.
- Subjects
RAPID eye movement sleep; SLEEP interruptions; PSYCHOLOGICAL resilience; NON-coding RNA; AMYGDALOID body; MICRORNA; POST-traumatic stress disorder
- Publication
Brain Sciences (2076-3425), 2021, Vol 11, Issue 4, p489
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci11040489