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- Title
Vitamin D levels in asthmatic patients with and without allergic bronchopulmonary aspergillosis.
- Authors
Agarwal, Ritesh; Sehgal, Inderpaul S.; Dhooria, Sahajal; Aggarwal, Ashutosh N.; Sachdeva, Naresh; Bhadada, Sanjay K.; Garg, Mandeep; Behera, Digambar; Chakrabarti, Arunaloke
- Abstract
Vitamin D deficiency is believed to be a pathogenetic factor in patients with allergic bronchopulmonary aspergillosis (ABPA) and cystic fibrosis. Whether vitamin D deficiency is also prevalent in ABPA complicating asthma, remains unknown. Herein, we evaluated vitamin D levels in asthmatic patients with and without ABPA. In a prospective study, plasma vitamin D (25[OH]D) levels were measured in consecutive subjects with asthma (n = 75), ABPA (n = 158) and healthy volunteers (n = 50). Vitamin D levels <20 ng/mL were considered as vitamin D deficiency. There was no difference in mean (95% CI) vitamin D levels between healthy controls (15.3 [12.7- 17.9]), asthmatics (19.2 [16.3- 22.1]) and subjects with ABPA (18.9 [16.9- 20.8]) (P = .22). Vitamin D deficiency was encountered in 70%, 64% and 65% of the healthy controls, asthmatics and ABPA subjects, respectively, and was not different between the groups (P = .79). There was no difference in the asthma control, pulmonary function, immunological findings and the severity of bronchiectasis, in patients with ABPA, with and without vitamin D deficiency. Vitamin D deficiency is equally prevalent in asthmatic patients with or without ABPA in the Indian subcontinent, and does not appear to play a major role in the pathogenesis of ABPA complicating asthma.
- Subjects
ASTHMATICS; VITAMIN D deficiency; DISEASE prevalence; ASPERGILLUS fumigatus; SINUSITIS
- Publication
Mycoses, 2018, Vol 61, Issue 6, p344
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.12744