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- Title
Case Reports. Chronic and acute Aspergillus meningitis.
- Authors
Moling, O.; Lass-Floerl, Cornelia; Verweij, P. E.; Porte, Monique; Boiron, P.; Prugger, Monika; Gebert, U.; Corradini, R.; Vedovelli, C.; Rimenti, G.; Mian, P.
- Abstract
Summary. Cerebral aspergillosis usually occurs in severely immunocompromized hosts, is difficult to diagnose, and has a poor prognosis. After 14 months of chronic meningitis, ventriculitis, choroid plexitis, and lumbar arachnoiditis, which was complicated by acute hydrocephalus, Aspergillus , suspected to be from the candidus group, was isolated from the cerebrospinal fluid (CSF) of a previously healthy man. Thereafter Aspergillus antigen was found in stored plasma and CSF samples. He was treated with voriconazole and itraconazole. In a haemodialysis patient affected by an acute meningococcal meningitis, following a 3-day symptom-free interval, symptoms and signs of acute meningitis had reappeared and were unresponsive to a broad antimicrobial coverage. However, they resolved within 5 days after liposomal amphotericin B treatment had been started. From his CSF Aspergillus -DNA was identified and Aspergillus fumigatus isolated by culture. These two different clinical cases show that Aspergillus -DNA and antigen detection tests represent an advance in the diagnosis and liposomal amphotericin B, voriconazole, and itraconazole are an advance in the treatment of Aspergillus meningitis.
- Subjects
ASPERGILLOSIS; BRAIN diseases
- Publication
Mycoses, 2002, Vol 45, Issue 11/12, p504
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1046/j.1439-0507.2002.00789.x