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- Title
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF LORNOXICAM AND TOLPERISONE HYDROCHLORIDE IN COMBINED DOSAGE FORM.
- Authors
Jadeja, Bindiya; Davadra, Prakash; Ramalingam, Murugan; Patel, Parula; Dhaduk, Dharmesh
- Abstract
Analysis of pharmaceutical product is very important as it concerned with life. Lorno×icam and Tolperisone Hydrochloride is use for the treatment of Osteoarthritis. Stability of the pharmaceutical product is most important, so that work is carried out to develop a new, simple, precise, accurate, validated stability indicating RP-HPLC method for estimation of Lorno×icam and tolperisone hydrochloride in combined dosage form. Separation of the drugs from the degradation products formed under stress condition was achieved on a YMC packed Cyno, 250mm × 4.6mm, 5 μm column in an isocratic mode with 0.05% TFA in Water: Methanol in the ratio of 65:35, v/v used as mobile phase at a flow rate of 1 mL min-1. The detector was operated at 264 nm and temp 30oC . The linearity was observed in the range of 0.5 - 30 μg/ml for lorno×icam and 9.37-562.5 μg/ml for tolperisone hydrochloride. The developed method was meets all the acceptance criteria for the validation of analytical method as per the ICH guideline. The assay of drug was found in acceptance range. A simple, precise and accurate stability indicating RP-HPLC method was developed for estimation of lorno×icam and tolperisone hydrochloride.
- Subjects
DOSAGE forms of drugs; COMBINATION drug therapy; OSTEOARTHRITIS treatment; MUSCLE relaxants; PRODUCT quality; CONFERENCES &; conventions; THERAPEUTICS
- Publication
Pharma Science Monitor, 2013, Vol 4, Issue 1, p3429
- ISSN
0976-9242
- Publication type
Article