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- Title
Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor.
- Authors
Xiaochen Wang; Weida Li; Dongfeng Zhao; Bin Liu; Yong Shi; Baohui Chen; Hengwen Yang; Pengfei Guo; Xin Geng; Zhihong Shang; Peden, Erin; Kage-Nakadai, Eriko; Mitani, Shohei; Ding Xue
- Abstract
During apoptosis, dying cells are swiftly removed by phagocytes. It is not fully understood how apoptotic cells are recognized by phagocytes. Here we report the identification and characterization of the Caenorhabditis elegans ttr-52 gene, which encodes a transthyretin-like protein and is required for efficient cell corpse engulfment. The TTR-52 protein is expressed in, and secreted from, C. elegans endoderm and clusters around apoptotic cells. Genetic analysis indicates that TTR-52 acts in the cell corpse engulfment pathway mediated by CED-1, CED-6 and CED-7 and affects clustering of the phagocyte receptor CED-1 around apoptotic cells. TTR-52 recognizes surface-exposed phosphatidylserine (PtdSer) in vivo and binds to both PtdSer and the extracellular domain of CED-1 in vitro. TTR-52 is therefore the first bridging molecule identified in C. elegans that mediates recognition of apoptotic cells by crosslinking the PtdSer 'eat me' signal with the phagocyte receptor CED-1.
- Subjects
CAENORHABDITIS elegans; TRANSTHYRETIN; APOPTOSIS; PHAGOCYTES; CELL receptors; PHOSPHATIDYLSERINES
- Publication
Nature Cell Biology, 2010, Vol 12, Issue 7, p655
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb2068