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- Title
ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244.
- Authors
Nishioka, C.; Ikezoe, T.; Takeshita, A.; Yang, J.; Tasaka, T.; Yang, Y.; Kuwayama, Y.; Komatsu, N.; Togitani, K.; Koeffler, H. P.; Taguchi, H.
- Abstract
A letter to the editor about the ability of the ZD6474 selective inhibitor of tyrosine kinases coding to induce growth arrest and apoptosis of human leukemia cells is presented.
- Subjects
LETTERS to the editor; PROTEIN-tyrosine kinase inhibitors; LEUKEMIA; CANCER chemotherapy; ANTINEOPLASTIC agents; APOPTOSIS; CELL physiology; COMPARATIVE studies; DRUG synergism; HETEROCYCLIC compounds; RESEARCH methodology; MEDICAL cooperation; PIPERIDINE; RESEARCH; TRANSFERASES; EVALUATION research; CANCER cell culture; PHARMACODYNAMICS
- Publication
Leukemia (08876924), 2007, Vol 21, Issue 6, p1308
- ISSN
0887-6924
- Publication type
letter
- DOI
10.1038/sj.leu.2404647