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- Title
Tryptophan hydroxylase 1 genotype modulates the associations between intolerance of uncertainty and loss-related risky preference: a preliminary study.
- Authors
Lin, Huiyan; Yang, Junkai; Hu, Jianping
- Abstract
Intolerance of uncertainty (IU) has been suggested to be associated with emotional perceptions and evaluations. Several studies have also revealed that IU is related to cognitive preferences, in particular gain-relevant risk preference. Nevertheless, it is still unclear whether both prospective and inhibitory IU, two dimensions of IU, predict gain-related and moreover, loss-relevant risky preference. More importantly, it is unknown whether the associations between IU and risk preference are modulated by biological factors (e.g., genes). Therefore, the current study investigated whether prospective and inhibitory IU were associated with gain-/loss-related risk preference and whether the associations were modulated by an impulsivity control-related gene, tryptophan hydroxylase 1 (TPH1) gene (A779C, rs1799913) through recruiting 222 healthy Chinese participants. Results showed that prospective IU was correlated with gain-relevant risk averse. There was not a significant association between IU and loss-relevant risk preference. Nevertheless, further analysis revealed that the association was modulated by the TPH1 genotype. Prospective and inhibitory IU predicted loss-relevant risk averse specifically for TPH1 AC genotype carriers but not for other genotype carriers (i.e., AA or CC). The findings emphasize the associations between IU and risk preference depending on frame and genetic variance.
- Subjects
TRYPTOPHAN hydroxylase; GENOTYPES; CHINESE people; LOSS aversion
- Publication
Current Psychology, 2024, Vol 43, Issue 5, p4654
- ISSN
1046-1310
- Publication type
Article
- DOI
10.1007/s12144-023-04668-0