We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of Insulin Resistance with Obesity in Children.
- Authors
Siddiqui, Shameem Ahmad; Bashir, Saira; Shabbir, Iffat; Sherwani, Misbah ul Islam Khan; Aasim, Muhammad
- Abstract
Background: Insulin resistance is the primary metabolic disorder associated with obesity. Little is known about its role as a determinant of the metabolic syndrome in obese children. Objectives: To assess the association of insulin resistance with metabolic syndrome in obese and non obese children. Study type and settings: Cross sectional analytical study conducted among children of ten Municipal Corporation high schools of Data Ganj Buksh Town Lahore. Subjects and Methods: A total of 46 obese and 49 non obese children with consent were recruited for the study. Fasting blood glucose, serum insulin, high density lipoprotein cholesterol, triglycerides, cholesterol, non HDL-cholesterol LDL-cholesterol were measured using standard methods. Data were analyzed by using statistical software SPSS-Version 15. Results: A total of 95 children 49 obese and 46 non obese were recruited for the study. A significant association of serum triglyceride (p<0.001), high density lipoprotein cholesterol (p<0.001), fasting blood glucose (p<0.001), and insulin levels (p<0.001), was seen between the two groups. For each component of metabolic syndrome, when insulin resistance increased so did odds ratios for cardio metabolic risk factors. Conclusions: Insulin resistance was seen in 34.7% children. Metabolic syndrome was found in 31.6% children reflecting that obese children are at high risk for metabolic syndrome and have low HDL-cholesterol and high triglycerides levels. Policy message: Obesity in children should be taken seriously by both parents and teachers with counseling for consulting experts to tackle this disease in early stages of disease.
- Subjects
OBESITY; INSULIN resistance; BODY mass index; HYPERTRIGLYCERIDEMIA; INSULIN; CHILDHOOD obesity; HIGH density lipoproteins; BLOOD lipoproteins
- Publication
Pakistan Journal of Medical Research, 2011, Vol 50, Issue 4, p137
- ISSN
0030-9842
- Publication type
Article