We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
LA TOXOPLASMOSE CEREBRALE DANS LE SERVICE DE MALADIES INFECTIEUSES DU CHU DU POINT G CHEZ LES PERSONNES VIVANT AVEC LE VIH.
- Authors
Konaté, I.; Sissoko, A. S.; Cissoko, Y.; Sogoba, D.; A. G. Mohamed, M. A.; Coulibaly, T. H.; Soumaré, M.; Magassoua, O.; Fofana, A.; Hassana, S.; Coulibaly, T.; Sacko, M.; Koné, Z.; Djimdé, S. O.; Bagayoko, I.; Dramé, M.; Guinto, C. O.; Dao, S.
- Abstract
Toxoplasmosis is defined as a cosmopolitan protozoan disease caused by an obligate intracellular coccidia, Toxoplasma gondii. The advent of HIV infection has made cerebral toxoplasmosis one of the most widespread neurological opportunistic infections. Method: We conducted a descriptive crosssectional study with retrospective review of files of cerebral toxoplasmosis on HIV infected patients who had been hospitalized in the infectious diseases department of Point G University Hospital between January 1st, 2014 and September 30th, 2019. Results: During the study period, the frequency of cerebral toxoplasmosis was 10.1% and in 46.4% of the patients, the diagnosis led to the discovery of HIV co-infection. The clinical features were characterized by fever, headaches, and motor deficit at 86.6%, 84.5% and 69.1% respectively. Roundel image on computed tomography was most represented and was found in 24.4% of patients. Anti-toxoplasma treatment based on trimethoprim /sulfamethoxazole (TMP/SMX) associated with folinic acid was initiated in 78 patients out of 90, but 19 patients had a contraindication or adverse effects to this combination and were treated with clindamycin. HAART was initiated in 31 patients out of 45 (68.9%) newly diagnosed. The overall prognosis was limited with a mortality rate of 42%. Conclusion: The prevalence of cerebral toxoplasmosis was high in our study, 10.1%. To reduce this prevalence, chemoprophylaxis should be initiated in all HIV-infected patients with a CD4 count below 200 cells/mm³.
- Publication
Mali Médical, 2022, Vol 37, Issue 4, p20
- ISSN
0464-7874
- Publication type
Article