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- Title
Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts.
- Authors
Murashima, Megumi; Watanabe, Shaw; Xing-Gang Zhuo; Uehara, Mariko; Kurashige, Atsushi
- Abstract
Little is known about the direct effect of broccoli sprouts on human health. So we investigated the effect of broccoli sprouts on the induction of various biochemical oxidative stress markers. Twelve healthy subjects (6 males and 6 females) consumed fresh broccoli sprouts (100 g/day) for 1 week for a phase 1 study. Before and after the treatment, biochemical examination was conducted and natural killer cell activity, plasma amino acids, plasma PCOOH (phosphatidylcholine hydroperoxide), the serum coenzyme Q_{10}, urinary 8-isoprostane, and urinary 8-OHdG (8-hydroxydeoxyguanosine) were measured. With treatment, total cholesterol and LDL cholesterol decreased, and HDL cholesterol increased significantly. Plasma cystine decreased significantly. All subjects showed reduced PCOOH, 8-isoprostane and 8-OHdG, and increased CoQ_{10}H_{2}/CoQ_{10} ratio. Only one week intake of broccoli sprouts improved cholesterol metabolism and decreased oxidative stress markers.
- Subjects
BIOMARKERS; SPROUTS; BROCCOLI; OXIDATIVE stress; METABOLISM
- Publication
Biofactors, 2004, Vol 22, Issue 1-4, p271
- ISSN
0951-6433
- Publication type
Article
- DOI
10.1002/biof.5520220154