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- Title
HIF-1 and AP-1 Cooperate to Increase Gene Expression in Hypoxia: Role of MAP Kinases.
- Authors
Michiels, Carine; Minet, Emmanuel; Michel, Gaetan; Mottet, Denis; Piret, Jean-Pascal; Raes, Martine
- Abstract
HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
- Subjects
TRANSCRIPTION factors; GENE expression; HYPOXEMIA
- Publication
IUBMB Life, 2001, Vol 52, Issue 1/2, p49
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1080/15216540252774766