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- Title
Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation.
- Authors
Spence, Shaun; Greene, Michelle K.; Fay, François; Hams, Emily; Saunders, Sean P.; Hamid, Umar; Fitzgerald, Marianne; Beck, Jonathan; Bains, Baljinder K.; Smyth, Peter; Themistou, Efrosyni; Small, Donna M.; Schmid, Daniela; O’Kane, Cecilia M.; Fitzgerald, Denise C.; Abdelghany, Sharif M.; Johnston, James A.; Fallon, Padraic G.; Burrows, James F.; McAuley, Daniel F.
- Abstract
The article presents research conducted by Shaun Spence and his colleagues on effect of sialic acid-decorated nanoparticle on inflammation in sepsis. Topics discussed include induction of oligomerization by the nanoparticles on macrophages; blocking of the production of lipopolysaccharide-induced inflammatory cytokines by nanoparticles; and therapeutic benefits of nanoparticle in in vivo murine models.
- Subjects
SEPTICEMIA treatment; SIALIC acids; NANOPARTICLES; OLIGOMERIZATION; MACROPHAGES; CYTOKINES; THERAPEUTICS
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 303, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aab3459