We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Atmospheric-Pressure Plasma- and TRAIL-Induced Apoptosis in TRAIL-Resistant Colorectal Cancer Cells.
- Authors
Ishaq, Musarat; Han, Zhao Jun; Kumar, Shailesh; Evans, Margaret D. M.; Ostrikov, Kostya (Ken)
- Abstract
The ideal anti-cancer treatments are those that can selectively kill cancer cells without harming normal cells. Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) is an example of a molecule that can selectively kill cancer cells but not normal cells. However, some tumors are resistant to the TRAIL treatment. We have recently shown that atmospheric cold non-equilibrium gas plasmas (AGPs) selectively induced cell death in melanoma and colorectal cancer cell lines by activating TNF and caspases 3/7 apoptosis pathways. Here, we demonstrated that AGPs can be used to make TRAIL-resistant colorectal cancer cells sensitive to the TRAIL treatment. AGPs plus TRAIL promoted the induction of the death receptor 5 (DR5), thereby enhancing the activation and apoptosis of ROS-dependent caspases 3/7. This study revealed the mechanisms involved in AGP-assisted TRAIL-induced cancer cell death and the associated synergistic effects that AGPs has on TRAIL-resistant colorectal cancer cells.
- Subjects
LIGANDS (Biochemistry); COLON cancer treatment; CANCER cells; APOPTOSIS; PLASMA gas research; CELL death; THERAPEUTICS
- Publication
Plasma Processes & Polymers, 2015, Vol 12, Issue 6, p574
- ISSN
1612-8850
- Publication type
Article
- DOI
10.1002/ppap.201400207