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- Title
Direct and Indirect Effects of Crisaborole Ointment on Quality of Life in Patients with Atopic Dermatitis: A Mediation Analysis.
- Authors
SIMPSON, Eric L.; YOSIPOVITCH, Gil; BUSHMAKIN, Andrew G.; CAPPELLERI, Joseph C.; LUGER, Thomas; STÄNDER, Sonja; TOM, Wynnis L.; PORTS, William C.; ZIELINSKI, Michael A.; TALLMAN, Anna M.; Huaming TAN; GERBER, Robert A.
- Abstract
Crisaborole ointment is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis. Using pooled data from two phase 3 studies (NCT02118766/NCT02118792), mediation modeling determined the interrelationship among pruritus, quality of life (QoL), and treatment. Patients aged = 2 years received crisaborole ointment, 2%, or vehicle twice daily for 28 days. QoL measures were Dermatology Life Quality Index (DLQI) (= 16 years) and Children's Dermatology Life Quality Index (CDLQI) (2-15 years). Pruritus was assessed by the Severity of Pruritus Scale (4-point scale from 0 to 3). The indirect effect of crisaborole on QoL mediated through its effect on pruritus was 51% (DLQI model, p < 0.05) and 72% (CDLQI model, p < 0.05). Direct effect (other effects) on QoL was 49% (DLQI model, p < 0.05) and 28% (CDLQI model, p > 0.05). Mediation modeling shows that crisaborole affects QoL mostly indirectly through pruritus severity reduction.
- Subjects
ATOPIC dermatitis; OINTMENTS; MEDIATION; QUALITY of life; PHOSPHODIESTERASE inhibitors
- Publication
Acta Dermato-Venereologica, 2019, Vol 99, Issue 9, p756
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3181