We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In Vivo Antimammary Tumor Effects of Soybean Extract with Targeted Lunasin (ET-Lun).
- Authors
Rusdi, Numlil Khaira; Purwaningsih, Erni Hernawati; Hestiantoro, Andon; Elya, Berna; Kusmardi, Kusmardi
- Abstract
Background/Objective: Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models in vivo. Methods: Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. Results: The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). Conclusions: These results indicated that the ET-Lun has anti-breast cancer activity in vivo.
- Subjects
BREAST cancer; EPIDERMAL growth factor receptors; ANIMAL disease models; TUMORS; AMINO acids
- Publication
Pharmacognosy Journal, 2021, Vol 13, Issue 5, p1269
- ISSN
0975-3575
- Publication type
Article
- DOI
10.5530/pj.2021.13.160