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- Title
Comparison of salivary beta-defensin-2 levels in chronic periodontitis with or without diabetes.
- Authors
Alex, Aleena; Vishnpriya, V.; Ponnulakshmi, R.; Gayathri, R.; Shyamaladevi, B.; Madhan, K.; Pillai, Adithya R.; Selvaraj, J.
- Abstract
Background: Chronic periodontitis (CP) is a common disease of an oral cavity consisting of chronic inflammation of the tissues. Patients with diabetes have increased incidence and severity of periodontal disease has been shown in earlier studies. Objective: The objective of this study was to study and compare the salivary levels of human beta-defensin (HBDF) protein concentration of healthy patients and people with gingivitis and CP. The different protein concentrations are not related to the frequency of periodontal pathogens, and it has a higher impact on salivary HBD-2 levels than bacteria. Materials and Methods: A total of 89 patients are enrolled in this study in which 31 periodontally healthy, 31 with CP with diabetes, and 27 with chronic diabetes. The HBD-2 ELISA kit will be obtained from bioarray technologies. The salivary BDF-2 will be quantified and evaluated using statistical analysis in one-way ANOVA. Results: The salivary HBD-2 protein concentration is higher in patients with CP compared with patients with diabetes. The salivary BDF-2 levels are higher in diabetic's patients with periodontitis than patients with non-diabetic periodontitis patients.
- Subjects
PERIODONTITIS; SALIVARY proteins; PERIODONTAL disease; ORAL diseases; DIABETES; PORPHYROMONAS gingivalis
- Publication
Drug Invention Today, 2019, Vol 12, Issue 4, p813
- ISSN
0975-7619
- Publication type
Article