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- Title
Formulation and evaluation of Torsemide nanoparticulate eye suspension.
- Authors
Akhil, Sharma; Sara, U. V. S.; Jha, K. K.; Shaweta, Sharma
- Abstract
Objective: The objective of the present work was to prepare Torsemide loaded nanoparticulate suspension to enhance ocular residence time with increased absorption from the eye & produce sustained pharmacological activity along with reduced dosing frequency. Method: In the present study, torsemide nanoparticles were prepared by single emulsion solvent evaporation method using ethyl cellulose as non-biodegradable polymer which was used to formulate a novel (1%) ophthalmic suspension for better contactability of the drug at the site of action. Result: The results showed that the method was reproducible, easy and efficient (regarding the entrapment of drug). The in vitro release studies indicated that the torsemide loaded ethyl cellulose nanoparticles provided sustained drug release (49.62%) in simulated tear fluid over a period of 12 h. Conclusion: The present work led to the conclusion that nanoparticulate suspension, thus prepared, could be an alternative to conventional ophthalmic preparations pertaining to its ability to sustain the drug release by reducing the dosing frequency resulting in better patient compliance.
- Subjects
NANOMEDICINE; DRUG absorption; DRUG dosage; ETHYLCELLULOSE; BIODEGRADATION; IN vitro studies; PATIENT compliance
- Publication
Drug Invention Today, 2014, Vol 6, Issue 1, p35
- ISSN
0975-7619
- Publication type
Article