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- Title
Association of uremic pruritus in hemodialysis patients with the number of days of high mean 24-hour particulate matter with a diameter of <2.5 μm.
- Authors
Ming-Hui Liu; Ming-Jen Chan; Ching-Wei Hsu; Cheng-Hao Weng; Tzung-Hai Yen; Wen-Hung Huang; Liu, Ming-Hui; Chan, Ming-Jen; Hsu, Ching-Wei; Weng, Cheng-Hao; Yen, Tzung-Hai; Huang, Wen-Hung
- Abstract
Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 μm [PM10] and PM with a diameter of <2.5 μm [PM2.5]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD). We analyzed the number of days of mean 24-hour PM10 ≥125 μg/m3/12 months (NDPM10) or the number of days of mean 24-hour PM2.5 ≥35 μg/m3/12 months (NDPM2.5) exceeding the standard level in the past 12 months respectively to determine the association with UP. In a multivariate logistic regression, HD duration, serum ferritin levels, low-density lipoprotein (LDL) levels, and NDPM2.5 ≥116 days/12 months were positively associated with UP. This cross-sectional study showed that the number of days on which the environmental PM2.5 exceeds the standard level might be associated with UP in patients on MHD.
- Subjects
HEMODIALYSIS patients; ITCHING; PARTICULATE matter; SKIN inflammation; LOW density lipoproteins
- Publication
Therapeutics & Clinical Risk Management, 2017, Vol 13, p255
- ISSN
1176-6336
- Publication type
journal article
- DOI
10.2147/TCRM.S129133